METTL3 improves spinal cord injury-associated locomotor function via SIRT1 m6A modification and regulation of neuronal ferroptosis
Knockdown of METTL3 enhances SIRT1 mRNA stability by regulating SIRT1 m6A modification to upregulate SIRT1, thereby suppressing ferroptosis and improving locomotor function in SCI rats.
Authors
- Ying Chen (ORCID: https://orcid.org/0000-0002-3036-4222)
- G. Chen
- Lian Wu (ORCID: https://orcid.org/0000-0003-0269-9962)
- Ruiqi Yang (ORCID: https://orcid.org/0000-0002-0276-2864)
- Kai Zeng (ORCID: https://orcid.org/0000-0002-5852-0952)
- Shaolin Li (ORCID: https://orcid.org/0000-0002-2214-721X)
- Bin Hu (ORCID: https://orcid.org/0009-0000-4602-4831)
Institutions
- Hunan City University (CN)
- Yichang Central People's Hospital (CN)
- The Eighth Hospital of Xi'an (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1080/01616412.2025.2578349
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00