Noninvasive Therapeutic Monitoring of Circulating Tumor DNA in BRAF‐Mutant Metastatic Colon Cancer Using Droplet Digital PCR, Next‐Generation Sequencing, and Fragmentomics
This case demonstrates the potential application of ctDNA and fragmentomics biomarkers, molecular analyses, and drug testing in noninvasive therapeutic monitoring of <i>BRAFV600E</i> mutant mCRC. These illustrate the potential application of such noninvasive therapeutic monitoring in larger scale cohorts of patients.
Authors
- Chit Chow (ORCID: https://orcid.org/0000-0002-2364-8331)
- Qing Zhou (ORCID: https://orcid.org/0000-0001-7737-9643)
- Rachel C.T. Lam (ORCID: https://orcid.org/0000-0002-1449-2953)
- Irene O L Tse (ORCID: https://orcid.org/0000-0001-6175-9262)
- K.C. Allen Chan (ORCID: https://orcid.org/0000-0003-1780-1691)
- Wei Kang (ORCID: https://orcid.org/0000-0002-4651-677X)
- W.K. Lam (ORCID: https://orcid.org/0000-0001-8922-5609)
- Brigette Ma (ORCID: https://orcid.org/0000-0003-4802-1102)
- Connie W. C. Hui (ORCID: https://orcid.org/0009-0006-8989-1293)
Institutions
- Chinese University of Hong Kong (HK)
- Hong Kong Science and Technology Parks Corporation (HK)
- Institute of Cancer Research (CA)
- Translational Research in Oncology (FR)
Publication Details
- Journal
- Case Reports in Oncological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/crom/8140524
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese University of Hong Kong