Multiscale simulation and parallel space–time adaptivity of calcium sparks in cardiac myocytes
The efficiency and speed gains in Calcium spark simulations are significant and enable modeling based research into previously difficult to tackle questions with regard to sub-micrometer scale models, e.g with respect to local interactions between the Sodium Calcium Exchanger and RyR clusters.
Authors
- Martin Falcke (ORCID: https://orcid.org/0000-0001-7137-1114)
- Wilhelm Neubert (ORCID: https://orcid.org/0009-0008-0553-1448)
- Nagaiah Chamakuri
Institutions
- Max Delbrück Center (DE)
- Indian Institute of Science Education and Research Thiruvananthapuram (IN)
Publication Details
- Journal
- Computer Methods and Programs in Biomedicine
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1016/j.cmpb.2025.109154
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Institute of Science Education and Research Thiruvananthapuram
- Deutsche Forschungsgemeinschaft
- Indian Institute of Science Education and Research Mohali