Density gradient centrifugation specifically improves sperm motility in hyperuricemia: evidence from intrauterine insemination cycles – retrospective cohort study

DGC specifically improves sperm motility in patients with HUA. While direct measurement of mechanistic markers (e.g., oxidative stress, metabolic factors) was not performed in this study, this motility-improving effect may correlate with DGC's known capacity to scavenge reactive oxygen species and optimize energy supply-an inference supported by prior mechanistic studies. However, improving sperm motility alone is insufficient to significantly enhance clinical pregnancy rates. These findings provide insights to optimize semen preparation strategies in HUA-associated male infertility.