Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis
Nucleosides, particularly adenosine, promote trophoblast proliferation. Adenosine has no additional effects on differentiation, apoptosis, or transcriptional changes in genes regulating its signaling or metabolism. Given adenosine's diverse biological roles beyond proliferation, further research is warranted to explore its broader impact on placental function and adaptation, especially under pathological conditions.
Authors
- Cilia Abad (ORCID: https://orcid.org/0000-0001-9951-7242)
- Mohammed Naji Husaen Ali
- Lukáš Červený (ORCID: https://orcid.org/0000-0002-1313-306X)
- František Štaud (ORCID: https://orcid.org/0000-0001-6712-097X)
- Michaela Novotná (ORCID: https://orcid.org/0000-0001-9114-3442)
- Mariia Adler
- Viktor Gala
Institutions
- Charles University (CZ)
- University Hospital Hradec Králové (CZ)
Publication Details
- Journal
- Placenta
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1016/j.placenta.2025.11.005
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00