Advanced quantitative MRI reveals a unique pattern of metabolic alterations and iron-pathology linked to glial activation in Baló's concentric sclerosis
BCS presents distinct metabolic and structural features compared to TDL, with biomarkers such as lower Cho/Cr ratios, elevated myo-inositol, and centrifugal QSM gradients, which may enhance diagnostic accuracy and provide insight into lesion expansion.
Authors
- Ioannis Papadopoulos (ORCID: https://orcid.org/0000-0001-8330-3960)
- Aigli G. Vakrakou (ORCID: https://orcid.org/0000-0002-7712-7216)
- Christine Stadelmann (ORCID: https://orcid.org/0000-0003-1766-5458)
- Maria‐Eleftheria Evangelopoulos (ORCID: https://orcid.org/0000-0003-4654-7477)
- Maria-Evgenia Brinia
- Georgios Velonakis (ORCID: https://orcid.org/0000-0002-0050-284X)
- G. Broumpoulis
- Constantinos Kilidireas
- Leonidas Stefanis
- Christina-Athanasia Dempegioti
- Efstratios Kravasilis (ORCID: https://orcid.org/0000-0002-7291-2231)
Institutions
- Democritus University of Thrace (GR)
- National and Kapodistrian University of Athens (GR)
- Universitätsmedizin Göttingen (DE)
- Eginition Hospital (GR)
Publication Details
- Journal
- Journal of Neuroimmunology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1016/j.jneuroim.2025.578798
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00