Model validation confirms variable relative biological effectiveness and elevated periventricular sensitivity after proton therapy of brain tumors
This study validates recently proposed voxel-wise and patient-wise predictive models for localization and occurrence of late radiation-induced contrast enhancements after proton therapy for brain tumors. Using an independent patient cohort, we confirmed the models' accuracy and reliability, emphasizing an increased radiosensitivity in periventricular regions and a linear-energy-transfer-dependent relative biological effectiveness.
Authors
- Armin Lühr (ORCID: https://orcid.org/0000-0002-9450-6859)
- Larissa S. Kilian
- Martina Palkowitsch (ORCID: https://orcid.org/0009-0009-7420-208X)
- Justus Thiem
- Mechthild Krause (ORCID: https://orcid.org/0000-0003-1776-9556)
- Annekatrin Seidlitz
- Arne Grey (ORCID: https://orcid.org/0000-0002-1511-8904)
- Fabian Hennings (ORCID: https://orcid.org/0000-0003-3988-4272)
- Steffen Löck (ORCID: https://orcid.org/0000-0002-7017-3738)
- Rebecca Bütof (ORCID: https://orcid.org/0000-0001-9576-9469)
- Esther G.C. Troost (ORCID: https://orcid.org/0000-0001-9550-9050)
Institutions
- TU Dortmund University (DE)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1016/j.radonc.2025.111271
- Citations
- 3
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.88