Rare and rapidly progressive crescentic proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a case series study

This single center retrospective study characterizes c-PGNMID in four patients. All cases exhibited IgG3<i>κ</i>/<i>λ</i>-restricted deposits, hypocomplementemia (3/4) and rapid progression to end-stage kidney disease (ESKD) despite aggressive immunosuppression. These findings highlight the need for novel therapies targeting clonal plasma cells or complement-mediated injury.