Single-cell immune landscape of acute kidney injury after cardiac surgery with cardiopulmonary bypass
To our knowledge, this is the first prospective study to integrate single-cell RNA-seq, flow cytometry, and protein microarray in cardiac surgery-related AKI. Our analysis identified distinct immune cells and identified key biomarkers, including CD69, CD28, CCL5, ICAM1, IL-16 and MIF as candidate pathway.
Authors
- Min Yan (ORCID: https://orcid.org/0000-0002-1355-1261)
- Wentong Meng
- Lei Du (ORCID: https://orcid.org/0000-0001-8173-5575)
- Zhenzhen Cheng (ORCID: https://orcid.org/0000-0003-2286-0004)
- Xinyi Liao (ORCID: https://orcid.org/0000-0001-8805-9442)
- Qinjuan Wu
- Jiayi Sun (ORCID: https://orcid.org/0000-0003-3598-9528)
- Tingting Wang (ORCID: https://orcid.org/0000-0001-8812-2579)
- Juan Wu (ORCID: https://orcid.org/0000-0001-6973-4641)
- Ping Yang (ORCID: https://orcid.org/0000-0002-0811-7989)
- Yuanyuan Yao (ORCID: https://orcid.org/0000-0002-7513-2919)
- Jiyue Xiong
Institutions
- Hong Kong Polytechnic University (HK)
- Chongqing University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Chengdu Second People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- State Key Laboratory of Biotherapy
- Chongqing Three Gorges University (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1080/0886022x.2025.2581506
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00