Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk
We present in silico and clinical evidence of the transfer of doravirine into breastmilk. However, based on these data, the infant's exposure to doravirine through breastmilk is not expected to be hazardous.
Authors
- Rick Greupink (ORCID: https://orcid.org/0000-0003-2599-7540)
- David Marinus Burger (ORCID: https://orcid.org/0000-0001-7279-2818)
- Angela Colbers (ORCID: https://orcid.org/0000-0002-0389-9934)
- Lena van der Wekken‐Pas (ORCID: https://orcid.org/0000-0001-8674-1448)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1002/bcp.70325
- Citations
- 1
- Primary Topic
- Breastfeeding Practices and Influences
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- ZonMw
- Radboud Universitair Medisch Centrum