<i>MYC</i> amplification and MYC protein expression are poor prognostic markers in pediatric and young adult osteosarcoma
MYC amplification and high protein expression both independently and concurrently predict poor survival in pediatric and young adult osteosarcoma, beyond metastatic status. Incorporating MYC status into risk stratification may enhance prognostic accuracy and inform targeted therapeutic development.
Authors
- Sreekar Challa
- Erin Alston (ORCID: https://orcid.org/0000-0002-1439-2258)
- Lorena Lazo de la Vega (ORCID: https://orcid.org/0000-0003-3609-0098)
- Andrew D. Cherniack (ORCID: https://orcid.org/0000-0003-0470-0111)
- Alanna J. Church (ORCID: https://orcid.org/0000-0002-4835-5770)
- Evelina Ceca
- Katherine A. Janeway (ORCID: https://orcid.org/0000-0001-6000-3594)
- Matthew Meyerson (ORCID: https://orcid.org/0000-0002-9133-8108)
- Yvonne Li (ORCID: https://orcid.org/0000-0002-1741-1995)
- Matthew Nagy (ORCID: https://orcid.org/0000-0001-5087-6674)
- Olivia Puopolo
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- Boston Children's Museum (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Cancer
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1002/cncr.70161
- Citations
- 2
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04