Astrocytic Ror2-induced imbalance in brain and gut homeostasis contributes to chronic post-thoracotomy pain
These findings suggest that the facilitation of CPTP development by Ror2 is associated with disruptions in the A1/A2 astrocytic balance, chemokine production in the ACC, and SCFA levels in the gut microbiota. Inactivation of astrocytic Ror2 may serve as a targeted treatment to restore the balance of reactive astrocytes and mitigate their pathogenic effects.
Authors
- Le Shen (ORCID: https://orcid.org/0000-0002-2563-0012)
- Afang Zhu (ORCID: https://orcid.org/0000-0001-9069-7945)
- Chaoqun Liu (ORCID: https://orcid.org/0000-0001-8322-3290)
- Li Xu (ORCID: https://orcid.org/0000-0003-2436-7758)
- Yuguang Huang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fnagi.2025.1675725
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16