Fixing a Mismatch: The Case for Age-Aligned Kidney Allocation

Despite recent advances, deceased donor kidney transplant allocation in the United States does not sufficiently account for the mismatch between donor and recipient age. This misalignment often leads to a suboptimal use of scarce resources. This viewpoint calls for restructuring of current kidney allocation strategies, advocating for a more intentional, age-matched approach that prioritizes better long-term quality kidneys for proportionally younger patients and encourages the use of older donor kidneys in similarly aged recipients. Drawing on the National Scientific Registry of Transplant Recipients data, clinical observations, and ethical reasoning, we argue that incorporating age in the organ allocation algorithms may improve both equity and utility in organ distribution. We also advocate for revision of the kidney donor risk calculators and placing a cap on the pre-emptive wait-time. Such realignments may reduce organ discard rates, enhance long-term graft utility, alleviate decision-making burdens on patients, and decrease the need for re-transplants on younger patients. To achieve this, recalibrations in allocation algorithms and reframing of what constitutes a "good" kidney are required. The goal is not to limit choice, but to structure a framework that maximizes benefit across populations while maintaining fairness towards a more sustainable model of transplant care.

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Publication Details

Journal
Transplant International
Published
2025-11-07
DOI
https://doi.org/10.3389/ti.2025.15148
Primary Topic
Renal Transplantation Outcomes and Treatments
Type
article
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article

Fixing a Mismatch: The Case for Age-Aligned Kidney Allocation

Melissa E. Chen, Esteban Calderon, Emmanouil Giorgakis, Chirag S. Desai et al.
Transplant International
Renal Transplantation Outcomes and Treatments
article

Fixing a Mismatch: The Case for Age-Aligned Kidney Allocation

Melissa E. Chen, Esteban Calderon, Emmanouil Giorgakis, Chirag S. Desai, Alex Toledo, Sorabh Kapoor, Kunal Kapoor
article en

Abstract

Despite recent advances, deceased donor kidney transplant allocation in the United States does not sufficiently account for the mismatch between donor and recipient age. This misalignment often leads to a suboptimal use of scarce resources. This viewpoint calls for restructuring of current kidney allocation strategies, advocating for a more intentional, age-matched approach that prioritizes better long-term quality kidneys for proportionally younger patients and encourages the use of older donor kidneys in similarly aged recipients. Drawing on the National Scientific Registry of Transplant Recipients data, clinical observations, and ethical reasoning, we argue that incorporating age in the organ allocation algorithms may improve both equity and utility in organ distribution. We also advocate for revision of the kidney donor risk calculators and placing a cap on the pre-emptive wait-time. Such realignments may reduce organ discard rates, enhance long-term graft utility, alleviate decision-making burdens on patients, and decrease the need for re-transplants on younger patients. To achieve this, recalibrations in allocation algorithms and reframing of what constitutes a "good" kidney are required. The goal is not to limit choice, but to structure a framework that maximizes benefit across populations while maintaining fairness towards a more sustainable model of transplant care.

Transplant InternationalVol. 38
University of North Carolina at Chapel Hill (US)
Openalex Percentile: Top 49%
Renal Transplantation Outcomes and Treatments
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Fixing a Mismatch: The Case for Age-Aligned Kidney Allocation — Melissa E. Chen, Esteban Calderon, et al. · Transplant International (2025) | TGRS Research Map | TGRS