A Rare Case of <i>t</i> (1; 19) Translocation in Acute Myeloid Leukemia: Evaluation of a High‐Risk Patients

Acute Myeloid Leukemia (AML) is a heterogeneous malignancy arising from the malignant transformation of hematopoietic stem cells, characterized by the accumulation of blasts in the myeloid lineage. While common cytogenetic alterations in AML play a critical role in prognostic classification, rare chromosomal translocations may have distinct impacts on disease biology and treatment response. In this report, we present a high-risk AML case harboring the <i>t</i>(1; 19) translocation. By highlighting the diagnostic and therapeutic challenges posed by this uncommon genetic aberration, this case aims to contribute to clinical practice in the field of hematology.

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Publication Details

Journal
Case Reports in Hematology
Published
2025-01-01
DOI
https://doi.org/10.1155/crh/4655315
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
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article

A Rare Case of t (1; 19) Translocation in Acute Myeloid Leukemia: Evaluation of a High‐Risk Patients

Abdullah Karakuş, Orhan Ayyıldız, Songül Beskisiz
Case Reports in Hematology
Acute Myeloid Leukemia Research
article

A Rare Case of t (1; 19) Translocation in Acute Myeloid Leukemia: Evaluation of a High‐Risk Patients

Abdullah Karakuş, Orhan Ayyıldız, Songül Beskisiz
article en

Abstract

Acute Myeloid Leukemia (AML) is a heterogeneous malignancy arising from the malignant transformation of hematopoietic stem cells, characterized by the accumulation of blasts in the myeloid lineage. While common cytogenetic alterations in AML play a critical role in prognostic classification, rare chromosomal translocations may have distinct impacts on disease biology and treatment response. In this report, we present a high-risk AML case harboring the <i>t</i>(1; 19) translocation. By highlighting the diagnostic and therapeutic challenges posed by this uncommon genetic aberration, this case aims to contribute to clinical practice in the field of hematology.

Case Reports in HematologyVol. 2025(1)
Dicle University (TR)
Openalex Percentile: Top 57%
Acute Myeloid Leukemia Research
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