Inhibition of BTK and SYK attenuates <i>Porphyromonas gingivalis</i> -induced activation of the pyroptosis pathway and inflammation in host cells
The pharmacological inhibition of BTK or SYK mitigates the pyroptotic pathway in hMDMs and exerts a broad anti-inflammatory effect in both hMDMs and hGFs. These results highlight the anti-inflammatory potential of BTK and SYK inhibitors for the treatment of periodontal disease.
Authors
- Alicja Płonczyńska (ORCID: https://orcid.org/0000-0002-4913-315X)
- Maja Sochalska (ORCID: https://orcid.org/0000-0002-6665-3309)
- Dorota Drapała (ORCID: https://orcid.org/0009-0006-1825-7172)
- Aureliusz Schuster (ORCID: https://orcid.org/0000-0002-3658-3733)
- Tomasz Kaczmarzyk (ORCID: https://orcid.org/0000-0003-3024-9926)
- Jan Potempa (ORCID: https://orcid.org/0000-0002-3600-7461)
- Aleksander M. Grabiec (ORCID: https://orcid.org/0000-0001-9472-850X)
- Magdalena Nowak (ORCID: https://orcid.org/0000-0002-9062-2772)
Institutions
- Jagiellonian University (PL)
- University of Louisville (US)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1080/20002297.2025.2577219
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowym Centrum Nauki