Elucidating the phytochemical profile of Sophorae Flavescentis Radix-Astragali Radix herb pair: an integrated LC-QTOF-MS/MS, pharmacological activity, and network pharmacology study on anti-hepatocellular carcinoma effects
Integrated pharmacological, chemical and computational evidence links the measurable anti-HCC efficacy of SF-AR to a bioavailable, multi-class phytochemical ensemble that converges on inflammation-driven survival pathways. SF-AR therefore emerges as a multi-target, low-toxicity therapeutic candidate that warrants further preclinical development for hepatocellular carcinoma.
Authors
- L. Qu
- Huarong Xu (ORCID: https://orcid.org/0000-0002-5726-6796)
- Jiameng Qu
- Zhiyuan Li (ORCID: https://orcid.org/0000-0003-3052-1109)
- Qing Li (ORCID: https://orcid.org/0000-0003-3087-4692)
- Yidi Yin
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fchem.2025.1687098
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00