Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion
Our work identifies a novel mechanism by which M1-Mφ regulate trophoblast migration and invasion through the CXCL9/STAT1/IRF1/ZEB1 axis, which in turn leads to the release of CCL2 that promotes macrophage infiltration in RSA, highlighting a new form of crosstalk between macrophages and trophoblasts.
Authors
- Jinli Ding (ORCID: https://orcid.org/0000-0003-4247-3335)
- Qiuji Wu (ORCID: https://orcid.org/0000-0002-4655-3108)
- Xiang Wang (ORCID: https://orcid.org/0009-0002-4130-0766)
- Hui Qiu (ORCID: https://orcid.org/0000-0002-2923-1019)
- Sisi Yan (ORCID: https://orcid.org/0009-0003-1342-9973)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Hubei Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1629370
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hubei Province
- Peking University
- Peking University Third Hospital
- Fundamental Research Funds for the Central Universities