Exosomal lncRNA XR_001793654.1 in human cardiac explant-derived alleviates atrial fibrillation via abolishing the miR-107-3p-mediated KLF13 inhibition
In conclusion, human CDC-derived EV containing XR_001793654.1 alleviates atrial fibrosis and AF through neutralizing miR-107-3p-mediated downregulation of KLF13. These findings offer new perspectives on AF molecular mechanisms and emphasize XR_001793654.1 as a promising intervention target.
Authors
- Huishan Wang (ORCID: https://orcid.org/0000-0001-6523-7488)
- Yanxiao Liang
- Yuan Tian (ORCID: https://orcid.org/0000-0001-6174-3359)
- Dongyu Li (ORCID: https://orcid.org/0000-0002-8793-3238)
Institutions
- Sheng Jing Hospital (CN)
- General Hospital of Shenyang Military Region (CN)
- Command Hospital (IN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fcell.2025.1694467
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00