Identification of novel phenotypes in pediatric sepsis based on blood glucose trajectories
GBTM effectively stratifies pediatric sepsis into distinct blood glucose trajectory phenotypes. Persistent severe hyperglycemia (Group 4) independently predicts in-hospital mortality, while slow-recovery hypoglycemia (Group 1) indicates a poor prognosis in septic shock. Phenotype-guided interventions are recommended: early insulin therapy (target blood glucose <10 mmol/L) for Group 4 and prophylactic glucose infusion (target >3.8 mmol/L) for Group 1.
Authors
- Wenjun Liu (ORCID: https://orcid.org/0000-0002-4044-7734)
- Jing Li (ORCID: https://orcid.org/0000-0002-5848-2781)
- Wang Ying (ORCID: https://orcid.org/0000-0003-3020-5317)
- Feng Xu (ORCID: https://orcid.org/0000-0002-2705-4207)
- Wendy H.C. Song (ORCID: https://orcid.org/0000-0002-3891-5092)
- Chengjun Liu (ORCID: https://orcid.org/0000-0002-4156-0181)
- Xianming Xu (ORCID: https://orcid.org/0000-0002-3019-725X)
- Shaojun Li (ORCID: https://orcid.org/0000-0002-3547-915X)
Institutions
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fped.2025.1663890
- Citations
- 1
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Chongqing Medical University