Vimentin immunization induces TH2/TH17 cell activation and autoantibody production in a novel mouse model of bleomycin induced systemic sclerosis
This improved model system offers dual advantages for advancing SSc research: it enables deeper mechanistic investigation of the interconnected pathways driving both fibrosis and autoimmune activation, while simultaneously providing a more relevant preclinical platform for evaluating novel therapeutic strategies targeting multiple disease components.
Authors
- Sang‐Uk Seo (ORCID: https://orcid.org/0000-0002-6633-1932)
- Sung Ho Jeon (ORCID: https://orcid.org/0000-0001-5982-140X)
- Seon-Yeong Lee (ORCID: https://orcid.org/0000-0003-4269-8657)
- Chae Rim Lee (ORCID: https://orcid.org/0000-0001-6537-5696)
- Tae Ho Kim
- Jeong Won Choi
- Jeonghyeon Moon (ORCID: https://orcid.org/0000-0002-5384-4077)
- Kun Hee Lee (ORCID: https://orcid.org/0000-0002-5380-3726)
- Jae-Deog Kim
- Mi‐La Cho (ORCID: https://orcid.org/0000-0001-5715-3989)
Institutions
- Pusan National University Dental Hospital (KR)
- Pusan National University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1639601
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47