Drug-induced headache reports: a comprehensive disproportionality and time-to-onset pharmacovigilance study using the FAERS database (2018–2024)
This large-scale pharmacovigilance study identifies multiple drugs and therapeutic classes with significant associations to headache as an ADR. These findings highlight the need for proactive headache monitoring, particularly during early treatment phases, and warrant further prospective investigations to understand mechanisms and preventive strategies.
Authors
- Omar Awad Alsaidan (ORCID: https://orcid.org/0000-0002-2848-2932)
- Azfar Athar Ishaqui (ORCID: https://orcid.org/0000-0003-0688-2625)
- Tauqeer Hussain Mallhi (ORCID: https://orcid.org/0000-0001-9957-5362)
- Muhammad Bilal Maqsood (ORCID: https://orcid.org/0000-0003-1358-0350)
- Narendar Kumar (ORCID: https://orcid.org/0000-0002-2648-3915)
- Sami I. Alzarea (ORCID: https://orcid.org/0000-0003-4007-4023)
- Abdullah Salah Alanazi (ORCID: https://orcid.org/0000-0002-8120-4018)
- Sultan M. Alshahrani (ORCID: https://orcid.org/0000-0002-6194-7092)
- Abdulaziz Ibrahim Alzarea (ORCID: https://orcid.org/0000-0003-0604-6299)
- Hassan H. Alhassan (ORCID: https://orcid.org/0000-0002-7174-9831)
- Aseel Awad Alsaidan (ORCID: https://orcid.org/0000-0003-0220-6160)
- Khalid Mubarak Orayj (ORCID: https://orcid.org/0000-0001-6651-2306)
Institutions
- St. Gregory's University (US)
- University of Sindh (PK)
- Jouf University (SA)
- Ministry of Health (SA)
- Taylor's University (MY)
- King Khalid University (SA)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fpain.2025.1670648
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Khalid University