The diagnostic value of global longitudinal strain on doxorubicin-induced cardiotoxicity in pediatric cancer patients: a cross-sectional study
This study suggests that GLS derived from STE may help identify early alterations in left ventricular function in pediatric patients receiving doxorubicin. Although reduced GLS was associated with systolic and diastolic dysfunction, differences were modest and within physiological limits. These findings highlight the potential role of GLS in cardiac monitoring, though further research is needed to confirm its diagnostic value.
Authors
- Sri Endah Rahayuningsih (ORCID: https://orcid.org/0000-0003-1396-5285)
- Dany Hilmanto (ORCID: https://orcid.org/0000-0003-3684-4144)
- Susi Susanah (ORCID: https://orcid.org/0000-0003-4052-512X)
- Nur Melani Sari (ORCID: https://orcid.org/0000-0002-9062-9624)
- Dyah Ayu Shinta Lesmanawati
- Dzulfikar Djalil Lukmanul Hakim (ORCID: https://orcid.org/0000-0001-8568-4613)
Institutions
- Dr. Hasan Sadikin General Hospital (ID)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fped.2025.1615563
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39