Attenuation of sepsis-induced myocardial injury by Xiangdan injection via mitochondrial protection and inflammation suppression in mice

Xiangdan injection conferred robust cardioprotection in sepsis, combining anti-inflammatory effects, reduction of cardiac injury markers, and preservation of mitochondrial structure. These outcomes are consistent with the known capacity of traditional Chinese medicine formulations to modulate TLR4/NF-κB and JAK2/STAT3 pathways, thereby supporting mechanistic suppression of these cascades in our model.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-11-07
DOI
https://doi.org/10.3389/fmed.2025.1669474
Primary Topic
Immune Response and Inflammation
Type
article
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article

Attenuation of sepsis-induced myocardial injury by Xiangdan injection via mitochondrial protection and inflammation suppression in mice

Hongxia Bai, Yuejin Chang, Jinbo Pan, Hui Li et al.
Frontiers in Medicine
Immune Response and Inflammation
article

Attenuation of sepsis-induced myocardial injury by Xiangdan injection via mitochondrial protection and inflammation suppression in mice

Hongxia Bai, Yuejin Chang, Jinbo Pan, Hui Li, Zhenhao Lin, Wenlei Zhang
article en

Abstract

Xiangdan injection conferred robust cardioprotection in sepsis, combining anti-inflammatory effects, reduction of cardiac injury markers, and preservation of mitochondrial structure. These outcomes are consistent with the known capacity of traditional Chinese medicine formulations to modulate TLR4/NF-κB and JAK2/STAT3 pathways, thereby supporting mechanistic suppression of these cascades in our model.

Frontiers in MedicineVol. 12
Third People's Hospital of Hangzhou (CN)
Openalex Percentile: Top 65%
Immune Response and Inflammation
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