Attenuation of sepsis-induced myocardial injury by Xiangdan injection via mitochondrial protection and inflammation suppression in mice
Xiangdan injection conferred robust cardioprotection in sepsis, combining anti-inflammatory effects, reduction of cardiac injury markers, and preservation of mitochondrial structure. These outcomes are consistent with the known capacity of traditional Chinese medicine formulations to modulate TLR4/NF-κB and JAK2/STAT3 pathways, thereby supporting mechanistic suppression of these cascades in our model.
Authors
- Hongxia Bai
- Yuejin Chang
- Jinbo Pan (ORCID: https://orcid.org/0000-0001-8246-1043)
- Hui Li (ORCID: https://orcid.org/0000-0003-4938-1783)
- Zhenhao Lin (ORCID: https://orcid.org/0000-0002-7843-3530)
- Wenlei Zhang
Institutions
- Third People's Hospital of Hangzhou (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fmed.2025.1669474
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00