Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties
PLD could be a promising multi-targeting candidate for treating neuropathic pain and motor dysfunction through its anti-inflammatory, antioxidant, and neuroprotective properties, acting on opioid and GABA receptors.
Authors
- Sajad Fakhri
- Sadaf Abdian (ORCID: https://orcid.org/0000-0001-5680-0806)
- Fatemeh Abbaszadeh (ORCID: https://orcid.org/0000-0001-8226-8649)
- Javier Echeverría (ORCID: https://orcid.org/0000-0002-1688-968X)
- Mohammad Mehdi Gravandi (ORCID: https://orcid.org/0000-0002-7995-5285)
- Amir Kiani (ORCID: https://orcid.org/0000-0002-7802-2117)
- Ehsan Mohammadi‐Noori (ORCID: https://orcid.org/0000-0002-1464-2691)
- Mohammad Hosein Farzaei (ORCID: https://orcid.org/0000-0001-7081-6521)
Institutions
- Universidad de Santiago de Chile (CL)
- Kermanshah University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fphar.2025.1691130
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00