Identification and experimental validation of common genes associated with both pulmonary arterial hypertension and major depressive disorder
This integrative analysis highlights genetic and molecular links between PAH and MDD. CHD8, DDX42, and EIF3D emerge as candidate hub genes associated with the coexistence of these conditions, suggesting hypotheses for mechanistic follow-up and potential therapeutic targeting.
Authors
- Liangdi Xie (ORCID: https://orcid.org/0000-0001-5544-3149)
- Guili Lian (ORCID: https://orcid.org/0000-0001-5909-3991)
- Mohammad Ismail Hajary Sagor (ORCID: https://orcid.org/0009-0005-3843-938X)
- Gufeng Gao (ORCID: https://orcid.org/0000-0001-6448-7215)
- Yan Yan (ORCID: https://orcid.org/0000-0002-8399-4818)
- Liang Chen (ORCID: https://orcid.org/0009-0003-8657-8769)
- Hung‐Ju Lin (ORCID: https://orcid.org/0000-0002-4577-7601)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fpsyt.2025.1670519
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China