Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development
These results highlight the importance of long-term immunologic monitoring, including assessments for immune dysregulation and anti-cytokine autoantibodies. Future therapies should consider adjunct strategies such as thymic regeneration or targeted immune modulation to address the underlying architectural defects in this disorder.
Authors
- Berna Savaş (ORCID: https://orcid.org/0000-0003-3971-1419)
- Selin Sevinç (ORCID: https://orcid.org/0000-0003-1001-7255)
- Sevgi Köstel Bal (ORCID: https://orcid.org/0000-0002-3718-5323)
- Ömer Suat Fitöz (ORCID: https://orcid.org/0000-0002-0180-0013)
- Figen Doğu (ORCID: https://orcid.org/0000-0002-7869-4941)
- Zehra Şule Haskoloğlu (ORCID: https://orcid.org/0000-0002-2668-0441)
- Kaan Boztuǧ (ORCID: https://orcid.org/0000-0001-8387-9185)
- Alphan Küpesiz (ORCID: https://orcid.org/0000-0001-8827-5567)
- Candan İslamoğlu (ORCID: https://orcid.org/0000-0002-8177-9348)
- Kamile Aydan İkincioğulları
- Nazlı Deveci (ORCID: https://orcid.org/0000-0002-3390-7798)
- Tanıl Kendirli (ORCID: https://orcid.org/0000-0001-9458-2803)
- Bernhard Ransmayr
- Kübra Baskın (ORCID: https://orcid.org/0000-0002-8934-869X)
Institutions
- Ankara University (TR)
- University of Health Science (KH)
- Akdeniz University (TR)
- St Anna Children's Hospital (AT)
- CeMM Research Center for Molecular Medicine (AT)
- Sağlık Bilimleri Üniversitesi (TR)
- Medical University of Vienna (AT)
- University of Health Sciences Antigua (AG)
- Gazi University (TR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1682642
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00