Effects of MAO-B and COMT Inhibitors on Sleep Disturbances in Patients With Parkinson’s Disease: A Network Meta-Analysis
These findings suggest that safinamide may offer additional value for managing sleep disruptions beyond its known motor benefits in patients with PD. Given the limited number and small scale of available trials, the overall evidence should be interpreted cautiously. Nonetheless, this analysis highlights the need for future high-quality trials focused on sleep outcomes to guide the personalized use of MAO-B and COMT inhibitors for sleep disturbances in PD patients.
Authors
- Seon-Min Lee (ORCID: https://orcid.org/0000-0003-0554-0906)
- Sung Ryul Shim (ORCID: https://orcid.org/0000-0003-4143-7383)
- Taeho Greg Rhee (ORCID: https://orcid.org/0000-0003-4961-3361)
- Yu Jin Jung (ORCID: https://orcid.org/0000-0003-4643-1968)
- Kyum-Yil Kwon
Institutions
- University of Connecticut (US)
- Konyang University (KR)
- Soonchunhyang University (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Yale University (US)
- Gangdong University (KR)
- Konyang University Hospital (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- UConn Health (US)
Publication Details
- Journal
- Journal of Movement Disorders
- Published
- 2025-11-07
- DOI
- https://doi.org/10.14802/jmd.25253
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Konyang University