Integrated CIRCLE-seq with RNA-seq to decipher the quantity, localization, and functional features of eccDNA in AML
This study unveils the eccDNA landscape in AML by direct CIRCLE-seq, linking its accumulation to transcriptional dysregulation and leukemogenesis, and highlights eccDNA as a potential biomarker and therapeutic target.
Authors
- Lijuan Gao (ORCID: https://orcid.org/0000-0002-7463-1134)
- Suning Chen (ORCID: https://orcid.org/0000-0001-6294-972X)
- C. Ruan
- Zhao Zeng (ORCID: https://orcid.org/0000-0001-8529-9782)
- Qiongyu Lu
- Hao Li (ORCID: https://orcid.org/0000-0002-1767-6475)
Institutions
- Soochow University (CN)
- People's Liberation Army 401 Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fonc.2025.1701989
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China