Cannabis use is associated with alterations in NLRP3 inflammasome related gene expression in monocyte-derived macrophages from people living with HIV
Overall, these findings suggest that CBD, as consumed through cannabis use, may mitigate NLRP3 activation in PWH, potentially offering therapeutic benefits for chronic inflammation. However, the unexpected effects on downstream cytokine mRNA expression, combined with product heterogeneity, underscore the need for future mechanistic studies to fully delineate cannabinoid-inflammasome interactions in the context of HIV.
Authors
- Bryant Avalos (ORCID: https://orcid.org/0000-0002-1863-2060)
- Scott Letendre (ORCID: https://orcid.org/0000-0003-3490-4975)
- Jerel Adam Fields (ORCID: https://orcid.org/0000-0002-8168-1412)
- Antoine Chaillon (ORCID: https://orcid.org/0000-0001-9490-3857)
- Anna Elizabeth Laird
- Jennifer E. Iudicello (ORCID: https://orcid.org/0000-0003-2854-7684)
- Debralee Cookson
- Ronald J. Ellis (ORCID: https://orcid.org/0000-0003-4931-752X)
- Lei Shu
- Matthew Spencer (ORCID: https://orcid.org/0009-0005-1865-5640)
- Melanie Crescini
- K.A. Walter (ORCID: https://orcid.org/0009-0004-0323-8222)
- Ali Boustani (ORCID: https://orcid.org/0000-0001-8146-7574)
- Mary Ford
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1634203
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Mental Health
- National Institute on Drug Abuse