Ninjurin-1 drives atherosclerosis progression via NF-κB/CXCL-8 activation in endothelial cells
Our results provide the first evidence that endothelial Ninj1 functions as a novel activator of the NF-κB/CXCL-8 axis, establishing its causal role in atherosclerosis and highlighting its potential as a targeted anti-inflammatory therapy.
Authors
- Nan Dong (ORCID: https://orcid.org/0000-0001-7950-0670)
- Ke Shen (ORCID: https://orcid.org/0000-0002-8656-6296)
- Zhihong Sun (ORCID: https://orcid.org/0000-0002-7605-2048)
- Wenjuan Ma (ORCID: https://orcid.org/0000-0002-1553-8992)
- Feng Ye
- Ning Ren (ORCID: https://orcid.org/0009-0009-4056-8577)
Institutions
- Shaoxing University (CN)
- Soochow University (CN)
- Xian Central Hospital (CN)
- Shaoxing Second Hospital (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1676216
- Citations
- 2
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.09