Cistanche deserticola-derived exosome-like nanovesicles target the Microbiota-GABA signaling axis to ameliorate loperamide-induced constipation
In summary, our study reveals a novel mechanism through which CELNs enhance intestinal motility via the microbiota-metabolite-host axis, offering a conceptual foundation and a potential nanotherapeutic strategy for the targeted treatment of constipation by modulating microbial homeostasis.
Authors
- Xinkun Bao
- Wenjie Xiao (ORCID: https://orcid.org/0009-0008-7727-2828)
- Kai Yan (ORCID: https://orcid.org/0000-0002-3420-818X)
- Jianwei Zhou (ORCID: https://orcid.org/0000-0002-1288-5905)
- Guangjun Sun
- Dazhi Yang (ORCID: https://orcid.org/0000-0003-0316-8346)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0002-2555-0311)
- Hao Wang (ORCID: https://orcid.org/0000-0002-2882-9596)
- Yiting Cai (ORCID: https://orcid.org/0000-0003-2971-1095)
- Aizhen Lin
- Xiaoyin Chen
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fphar.2025.1693366
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province
- Natural Science Foundation of Hubei Province
- Hubei University
- National Key Research and Development Program of China