Nrf2-mediated mechanistic pathways of celastrol nephroprotection: disrupting the oxidative-inflammatory-apoptotic axis in cypermethrin toxicity
Celastrol protects against cypermethrin nephrotoxicity through modulation of antioxidative, anti-inflammatory, and anti-apoptotic mechanisms. Correlation analysis suggests a potential role for Nrf2 in celastrol's integrated nephroprotective effects.
Authors
- Ashraf Albrakati (ORCID: https://orcid.org/0000-0002-4116-7865)
Institutions
- Taif University (SA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fphar.2025.1670444
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taif University