A randomized controlled trial of Shengji ointment combined with bromelain in promoting healing of tendon-exposed diabetic foot wounds: integrated 16S rDNA sequencing and metabolomics analysis
The Shengji ointment combined with bromelain has shown notable effectiveness in treating diabetic foot wounds with tendon exposure by modulating microbial composition (reducing pathogenic bacteria and increasing beneficial bacteria) and optimizing the metabolic environment (targeting key metabolic pathways), providing valuable insights for further exploration of its mechanisms.
Authors
- Junying Song (ORCID: https://orcid.org/0000-0002-9816-4454)
- Junchao Sun (ORCID: https://orcid.org/0009-0006-1538-781X)
- Xu Sun (ORCID: https://orcid.org/0000-0003-3337-4896)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fphar.2025.1666278
- Citations
- 1
- Primary Topic
- Pineapple and bromelain studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Tianjin Municipal Health Commission
- Tianjin University
- Tianjin Municipal Education Commission
- National Key Research and Development Program of China