STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation
SJZD had a definitely inhibitive effect against GC in mice by regulation the STAT3 expression in JAK/STAT signaling pathway, providing a mechanistic rationale for the potential clinical translation of SJZD in GC treatment.
Authors
- Haidan Wang (ORCID: https://orcid.org/0000-0002-6866-9427)
- Guiping Xie
- Qianqian Tan
- Yaohui Wang (ORCID: https://orcid.org/0000-0001-6434-5356)
- Xiaoyu Luo (ORCID: https://orcid.org/0000-0002-9447-2716)
- Jing Zhai (ORCID: https://orcid.org/0009-0002-4679-0039)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fmolb.2025.1683806
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00