Salivary oxidative stress persists in inflammatory bowel disease regardless of biological treatment response
Salivary AOPPs reflect baseline disease severity but do not predict response to biologics. Persistent AOPPs accumulation despite clinical control suggests a decoupling between clinical remission and oxidative homeostasis. Understanding the drivers and clinical relevance of persistent AOPPs is needed before considering potential therapeutic applications, such as antioxidant-based adjunctive strategies or interventions targeting AOPP-mediated damage, to improve remission rates in IBD patients receiving advanced treatments.
Authors
- Maura Lodovici (ORCID: https://orcid.org/0000-0001-8611-257X)
- Cristina Luceri (ORCID: https://orcid.org/0000-0003-1232-8778)
- Andrea Galli (ORCID: https://orcid.org/0000-0001-5416-6290)
- Elisabetta Bigagli (ORCID: https://orcid.org/0000-0003-1892-4343)
- Gabriele Dragoni (ORCID: https://orcid.org/0000-0001-5752-5113)
- Tommaso Innocenti (ORCID: https://orcid.org/0000-0002-2154-0490)
- Francesco Pindozzi
Institutions
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Florence (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fphar.2025.1699252
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Firenze