Impact of biologic therapy on blood cell indices and exacerbation risk in severe asthma: predictive value of the neutrophil-to-eosinophil ratio

Biologic therapy significantly reduced eosinophils and altered NER in severe asthma. Prominently, elevated post-treatment neutrophils, monocytes, and particularly a higher NER, were significant predictors of poorer asthma control and increased exacerbation risk, offering clinically useful biomarkers for personalized management.