Dynamic <scp> <sup>13</sup> C </scp> ‐ <scp>MRI</scp> of Branched‐Chain Amino Acid Metabolism Using Hyperpolarized [1‐ <scp> <sup>13</sup> C </scp> ]2‐Ketoisocaproate: A Multiband <scp>IDEAL</scp> Spiral Approach in Rodents and Pigs
The presented <sup>13</sup>C-MRI strategy enables efficient spectral separation and high-temporal-resolution imaging of KIC metabolism in rodents and pigs, establishing a translatable framework for noninvasive studies of BCAA metabolism.
Authors
- Jan Henrik Ardenkjær‐Larsen (ORCID: https://orcid.org/0000-0001-6167-6926)
- Rie Beck Olin (ORCID: https://orcid.org/0000-0003-1718-8196)
- Magnus Karlsson (ORCID: https://orcid.org/0000-0001-7738-1700)
- Mathilde H. Lerche (ORCID: https://orcid.org/0000-0002-5899-2781)
- Ditte Bentsen Christensen
- Ingeborg S. Skre (ORCID: https://orcid.org/0000-0003-3441-9419)
Institutions
- Technical University of Denmark (DK)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1002/mrm.70167
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00