The <i>JAK2V617F</i> and <i>CALR</i> mutations and risk of cancer, cardiovascular diseases, and all‐cause mortality
CH-defined by the JAK2V617F and CALR mutations-was associated with cancer, MPN, all-cause mortality-even with VAF < 1%-and vascular diseases at VAF ≥ 1%. These are novel findings, indicating that the JAK2V617F and CALR mutations confer an oncogenic potential with a VAF below the current CH of indeterminate potential definition.
Authors
- Henrik Enghusen Poulsen (ORCID: https://orcid.org/0000-0003-4242-9924)
- Christina Ellervik (ORCID: https://orcid.org/0000-0002-3088-4375)
- Johanne Gudmand‐Hoeyer (ORCID: https://orcid.org/0000-0002-4972-0653)
- Lasse Kjær (ORCID: https://orcid.org/0000-0001-6767-0226)
- Thomas Stiehl (ORCID: https://orcid.org/0000-0001-9686-9197)
- Troels Wienecke (ORCID: https://orcid.org/0000-0002-5389-1105)
- Marie Hvelplund Kristiansen (ORCID: https://orcid.org/0000-0003-4285-6766)
- Hans Carl Hasselbalch (ORCID: https://orcid.org/0000-0003-3936-8032)
- Anders Lindholm Sørensen (ORCID: https://orcid.org/0000-0002-0360-1595)
- Johnny T. Ottesen (ORCID: https://orcid.org/0000-0002-9786-0300)
- Morten Kranker Larsen (ORCID: https://orcid.org/0000-0002-2873-5928)
- Vibe Skov (ORCID: https://orcid.org/0000-0003-0097-7826)
- Morten Andersen (ORCID: https://orcid.org/0000-0001-7582-0685)
- Sabrina Cordua (ORCID: https://orcid.org/0000-0002-0585-7957)
- Christina Schjellerup Eickhardt‐Dalbøge (ORCID: https://orcid.org/0000-0002-0740-0555)
- Trine Alma Knudsen (ORCID: https://orcid.org/0000-0001-9829-3099)
- M. Hauer Jensen (ORCID: https://orcid.org/0000-0002-0164-4161)
- Jordan Andrew Snyder
Institutions
- Roskilde University (DK)
- University of Copenhagen (DK)
- Boston Children's Hospital (US)
- Harvard University (US)
- Frederiksberg Hospital (DK)
- Copenhagen University Hospital (DK)
- Zealand University Hospital (DK)
- Slagelse Hospital (DK)
- Zealand University Hospital Køge (DK)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1111/joim.70037
- Citations
- 2
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- Dagmar Marshalls Fond
- Lundbeckfonden
- TrygFonden
- Region Sjælland
- H. Lundbeck A/S
- Candys Foundation