Efficacy and Tolerability of Metyrapone in Mild Autonomous Cortisol Secretion: Real‐World Findings From Clinical Practice
Evening metyrapone was associated with significant reductions in systolic and diastolic blood pressure in patients with MACS, without causing adrenal insufficiency, indicating its potential safe clinical utility. A well-powered, controlled, prospective study is needed to validate these findings and comprehensively investigate the broader metabolic outcomes.
Authors
- John Newell‐Price (ORCID: https://orcid.org/0000-0002-0835-5493)
- Ahmed Iqbal (ORCID: https://orcid.org/0000-0002-5648-0539)
- Miguel Debono (ORCID: https://orcid.org/0000-0002-1059-9702)
- Simon Berry (ORCID: https://orcid.org/0009-0007-9100-8778)
Institutions
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1111/cen.70056
- Citations
- 1
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.29