Jaw-specific differential kinase activity profiles in human periodontal ligament stem cells under mechanical compression
These findings support our hypothesis that localized differences in kinase signaling may constitute a molecular basis for the clinically observed jaw-specific phenomena, such as heterogeneous orthodontic tooth movement and alveolar bone remodeling. Jaw-dependent mechanotransduction pathways can therefore be considered key determinants of periodontal biology and may provide a basis for follow-up studies aimed at enabling the development of personalized orthodontic and regenerative strategies.
Authors
- Emiel P. C. van der Vorst (ORCID: https://orcid.org/0000-0001-5771-6278)
- Michael Wolf (ORCID: https://orcid.org/0000-0002-5882-3080)
- Rogerio B. Craveiro (ORCID: https://orcid.org/0000-0003-0768-935X)
- Leon J. Schurgers (ORCID: https://orcid.org/0000-0001-7867-6957)
- Frank Hölzle (ORCID: https://orcid.org/0000-0002-2298-3517)
- Sanne L. Maas (ORCID: https://orcid.org/0000-0003-1423-8901)
- Yang Shi (ORCID: https://orcid.org/0000-0002-3336-4826)
- Christian Niederau
Institutions
- Maastricht University (NL)
- Universitätsklinikum Aachen (DE)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s13287-025-04778-5
- Citations
- 2
- Primary Topic
- dental development and anomalies
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Corona-Stiftung
- Deutsche Forschungsgemeinschaft
- RWTH Aachen University