Genomic Instability is Widespread in Esophageal Squamous Dysplasia and Increases During the Progression to Cancer
Mutations in <i>TP53</i> and <i>MUC5B</i>, as well as deletion of <i>CASP8</i>, may be early driver events in carcinogenesis and could precede the emergence of the APOBEC mutation signature. Moreover, ploidy alterations confer a selective advantage to genomically unstable cells, thereby promoting their progression toward malignant transformation. Collectively, our results demonstrate that genomic instability is prevalent in precancerous lesions and intensifies during the late stages of tumor progression. Cells with a certain level of genomic instability appear to possess a competitive advantage for malignant transformation.
Authors
- Shujun Cheng (ORCID: https://orcid.org/0000-0001-5672-8461)
- Ting Xiao (ORCID: https://orcid.org/0000-0002-9000-1909)
- Liyan Xue (ORCID: https://orcid.org/0000-0001-5185-0126)
- Haiyin An (ORCID: https://orcid.org/0000-0001-9086-2111)
- Xiuli Zhu
- Junyi Li (ORCID: https://orcid.org/0000-0001-5320-1621)
- Xian Cheng (ORCID: https://orcid.org/0000-0003-1140-3318)
- Guiqi Wang (ORCID: https://orcid.org/0000-0002-7253-1156)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- Beijing Chest Hospital (CN)
- Beijing Research Institute of Mechanical and Electrical Technology (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-10-31
- DOI
- https://doi.org/10.31083/fbl41107
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.05