polr2i is Required for Zebrafish Early Cardiac Development
Knockdown of the <i>polr2i</i> gene not only impairs cardiac structure and function but also disrupts the normal developmental asymmetry of multiple organs. These findings enhance our understanding of <i>polr2i</i> gene's role in CHD and underscore its potential as a therapeutic target.
Authors
- Shu-Ting Huang (ORCID: https://orcid.org/0000-0002-5937-7502)
- Xiaoyan Peng (ORCID: https://orcid.org/0000-0003-1547-8245)
- Hua Cao (ORCID: https://orcid.org/0000-0001-5480-1610)
- Yu‐Kun Chen (ORCID: https://orcid.org/0000-0001-9966-3979)
- Qiang Chen (ORCID: https://orcid.org/0000-0003-3768-9000)
- Xinrui Wang (ORCID: https://orcid.org/0000-0002-7383-9128)
- Yuqing Lei (ORCID: https://orcid.org/0000-0002-9445-1157)
- Qiuping Zhang
Institutions
- Fujian Medical University (CN)
- Fujian Women and Children Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-10-13
- DOI
- https://doi.org/10.31083/fbl44633
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian Medical University
- Fujian Provincial Health Commission