On-DNA Synthesis of 2-Hydroxy Dithiocarbamates
We present a modular on-DNA bridging strategy that addresses key reactivity challenges in DNA-encoded library synthesis. By generation of a reactive carbamodithioic acid intermediate from secondary amines, this method enables efficient coupling with epoxides to produce diverse 2-hydroxy dithiocarbamate scaffolds. Gentle and DNA-compatible, it offers a versatile platform for rapid, structurally diverse DEL construction with significant drug discovery potential.
Authors
- Hongli Cao (ORCID: https://orcid.org/0000-0002-5562-7244)
- Y. Wang (ORCID: https://orcid.org/0000-0002-0825-3809)
- Kexin Yang
- Haiqian Zhu
- Lijun Xue (ORCID: https://orcid.org/0000-0001-7793-3165)
- Yun Jin Hu (ORCID: https://orcid.org/0000-0001-6943-2459)
- Huimin Sun (ORCID: https://orcid.org/0000-0002-2892-5596)
- Kehan Zhou
Institutions
- University of Nottingham Ningbo China (CN)
- Pharmaron (United Kingdom) (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c04222
- Citations
- 1
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.81