Cathepsin S Contributes to Bladder Fibrosis Following Bladder Outlet Obstruction via IL-6 Trans-signaling
These findings indicate that CTSS contributes to BOO-induced bladder dysfunction and fibrosis by activating IL-6 trans-signaling through cleavage of IL-6R. CTSS may represent a potential therapeutic target for mitigating bladder fibrosis in BPH.
Authors
- Xilei Liu
- Tianyu Shen (ORCID: https://orcid.org/0000-0003-0550-1800)
- Hong Wang (ORCID: https://orcid.org/0000-0002-1300-9595)
- Mengchen Yang
- Liang Wang (ORCID: https://orcid.org/0009-0003-9051-2260)
Institutions
- Nankai University (CN)
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-10-31
- DOI
- https://doi.org/10.31083/fbl45355
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin Medical University
- National Key Research and Development Program of China