Astragalus Polysaccharide Improves Myocardial Fibrosis in Hypertrophic Cardiomyopathy Through the TGF-β1/Smad3 Signal Pathway
APS exerts cardioprotective and antifibrotic effects in HCM by inhibiting the TGF-β<sub>1</sub>/Smad3 signaling pathway. These findings highlight APS as a promising therapeutic candidate for targeting myocardial fibrosis and improving outcomes in HCM.
Authors
- Wenjun Wu (ORCID: https://orcid.org/0009-0003-8680-7699)
- B Li (ORCID: https://orcid.org/0009-0006-4486-6115)
- Nana Qin (ORCID: https://orcid.org/0009-0009-4437-2678)
Institutions
- Jilin University (CN)
- Changchun University of Chinese Medicine (CN)
- General Hospital of Shenyang Military Region (CN)
- Jilin Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-10-29
- DOI
- https://doi.org/10.31083/fbl45595
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39