Changes of Microglial Cells in the Progression of Neurodegeneration in Natural Prion Disease
Overall, we conclude that the observations described here support a potential failure of microglial cells that could perhaps lead to their inability to perform some of their physiological functions, maybe due to a senescent state. Gaining insight into the multifaceted roles of neuroglia in central nervous system (CNS) diseases is of critical importance in knowledge and understanding of CNS disease pathogenesis, but also in generating novel therapeutic strategies.
Authors
- María José Luesma Bartolomé (ORCID: https://orcid.org/0000-0003-4071-1467)
- Moisès Garcés (ORCID: https://orcid.org/0000-0002-1756-5492)
- Marta Monzón (ORCID: https://orcid.org/0000-0002-2787-9671)
- Jordi Pérez (ORCID: https://orcid.org/0000-0003-2303-1339)
- Rodrigo S. Hernández
- Juan José Badiola (ORCID: https://orcid.org/0000-0002-7173-7216)
- Rocío Sarasa
Institutions
- Universidad de Zaragoza (ES)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-10-31
- DOI
- https://doi.org/10.31083/fbl47074
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00