Functional role of granulocytic myeloid-derived suppressor cells in CAR-T therapy: insights from single-cell RNA sequencing in multiple myeloma
This study provides preliminary insights into the functional role of G-MDSCs in the MM TME and highlights their impact on CAR-T therapy outcomes. The findings suggest potential therapeutic strategies, including targeting PTGS1, to enhance CAR-T efficacy. Larger and more diverse cohorts are required to substantiate these observations.
Authors
- An Fang
- Chao Zhang (ORCID: https://orcid.org/0000-0001-6418-8370)
Institutions
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/08923973.2025.2585083
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05