In sepsis-associated cardiotoxicity, remifentanil reduces oxidative stress, inflammation, and apoptosis to maintain mitochondrial biogenesis by inhibiting NFkB and cas-3 immunoexpressions and enhancing SIRT1 upregulation
REMI exhibits significant cardioprotective effects in LPS-induced SIC by attenuating inflammation, oxidative stress, and apoptosis while preserving mitochondrial homeostasis.
Authors
- Muhammet Yusuf Tepebaşı (ORCID: https://orcid.org/0000-0002-1087-4874)
- Halil Aşçı (ORCID: https://orcid.org/0000-0002-1545-035X)
- Esma Selçuk (ORCID: https://orcid.org/0000-0002-1481-7834)
- Dinçer Uysal (ORCID: https://orcid.org/0000-0002-8498-9076)
- Duygu Yüksel (ORCID: https://orcid.org/0000-0002-3239-3932)
- Özlem Özmen (ORCID: https://orcid.org/0000-0002-5392-1626)
- Ahmet Bi̇ndal (ORCID: https://orcid.org/0000-0002-1971-6856)
Institutions
- Gümüşhane University (TR)
- Suleyman Demirel University (KZ)
- Burdur Mehmet Akif Ersoy Üniversitesi (TR)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1080/08923973.2025.2585087
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00