Edaravone dexborneol attenuates neuroinflammation in acute cerebral ischemia-reperfusion injury through the CXCL13/CXCR5/NF-κB pathway
Our results validate the protective efficacy of Edaravone dexborneol in OGD/R-induced microglia and MCAO rats. This effect may be attributed to its ability to mitigate neuroinflammation by modulating microglial M1/M2 polarization <i>in vitro</i> and inhibiting the CXCL13/CXCR5 axis and its associated NF-κB signaling pathway <i>in vivo</i>.
Authors
- Weichuan Wu
- Yanqing Yin
- Donghai Men
- Zixiong Huang (ORCID: https://orcid.org/0000-0003-1602-6830)
- Heng Lin (ORCID: https://orcid.org/0000-0002-1937-2264)
Institutions
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/08923973.2025.2585085
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00