Lewis Acid-catalyzed Formal 1,3-Hydroxy Migration of Arylvinyl Carbinols
Abstract Although the 1,3-hydroxy migration reaction of arylvinyl carbinols is a valuable molecular transformation, examples of Lewis acid-catalyzed reactions remain quite limited. We found that the target Lewis acid-catalyzed reaction proceeded smoothly when acetone was used as the reaction medium. This catalytic system was applicable to arylvinyl carbinols having electron-deficient aromatic rings, a little-studied and challenging topic in 1,3-hydroxy migration chemistry.
Authors
- Keiji Mori (ORCID: https://orcid.org/0000-0002-9878-993X)
- Tomoko Kawasaki‐Takasuka (ORCID: https://orcid.org/0000-0002-8468-7553)
- Koutarou Amano
Institutions
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Synlett
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1055/a-2740-4940
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00